Entrustable Professional Activities (EPAs) are a key practical framework and methodology in competency-based medical education (CBME). They assess learners' ability to independently perform clinical tasks through specific, observable, and delegated clinical tasks. Applying EPAs to nurse anesthetist (NA) training effectively integrates theory and practice, competence and empowerment, and promotes the development of their clinical competence. EPAs emphasize "clinical tasks that can be delegated to a learner for independent completion," which aligns closely with the clinical role of the nurse anesthetist. Anesthesia is a highly specialized and time-sensitive profession, requiring nurse anesthetists to demonstrate real-time judgment, technical skills, and patient safety monitoring in rapidly evolving clinical situations. Introducing EPAs into nurse anesthetist training helps learners integrate knowledge, skills, and attitudes, developing independent clinical competence. It also provides educators with a clear teaching and assessment framework, enhancing training quality and clinical safety.