Sngception is a unique somatosensory function of sensing acidosis, in which “sng” is the Romanization form of the Taiwanese word 痠 or similar to soreness in English. Of note, sng is derived from a linguistic phenomenon where both “sour taste” and muscle soreness are encoded in the same word in the Taiwanese language, which is only unique to Sino-Tibetan language family, but not in other languages. Linguistically, sng is a synthesis sensation, which may comprise soreness/aching (delayed onset muscle soreness), morbid soreness (myofascial pain, fibromyalgia), heaviness (acupuncture), and tightness (lumbar stenosis). Clinically, sng is a distinguishable symptom from pain in fibromyalgia and degenerative spine diseases, and commonly occurred in patients after spine surgery. After 6 years team efforts with many interdisciplinary and international collaborations, we demonstrated proprioceptors can transmit sngception and thus be considered as one type of sngceptors (sensory neurons sensing acidosis). We further found that activating ASIC3 of proprioceptive sngceptors can induce a priming effect that leads to “pain” chronicity. This paradigm-shifting discovery has fundamentally changed our understanding of human sensory systems and challenged the central dogma of pain biology that has been established in the past 50 years. This partially explains why current analgesics have little effect to relieve “pain” of fibromyalgia, as the chronic sng is not treated. In addition, the ASIC-dependent sngception can be antinociceptive as commonly used in several pain management approaches such as therapeutic ultrasound and dextrose prolotherapy. Understand the difference between sng and pain is essential for the precision medicine in sng and pain management, so that we can avoid the usage of non-effective pain killers for sng and facilitate the development of novel treatments for chronic sng and pain.