Inhalation anesthetics like isoflurane (introduced in 1981), sevoflurane (1990), and desflurane (1992) have been used in modern anesthetic practice for several decades. Most studies examined inspiratory and end-tidal concentrations to determine their pharmacokinetics (uptake, distribution, and elimination) and pharmacodynamics (MAC, amnesia, and hemodynamic stability). Our team expanded on this by characterizing inspiratory, end-tidal, arterial blood, and mixed venous blood concentrations during all phases of anesthesia (induction, maintenance, and recovery) in human and animal models. Our work has provided deeper insights into tissue solubility, wash-in and washout efficiency, and the predictability of emergence. Nowadays, the high global warming potential of volatile anesthetics has led to a growing emphasis on their environmental impact. Consequently, contemporary anesthetic practice increasingly considers both patient-centered outcomes and ecological sustainability.